Anti-c-Mpl Antibody (E-7) is a mouse monoclonal IgM κ c-Mpl antibody, cited in 1 publications, provided at 200 µg/ml; specific for an epitope mapping between amino acids 531-569 near the C-terminus of c-Mpl …
C-MPL cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each C-MPL of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Temperature range, -20+55 °C, for any mounting position at vertical wall, A similar pull-down assay, using anti-c-Mpl showed no binding of LOX-PP to the TPO receptor (data not shown). This was .. 2001;80:284–91. doi: 10.1007/ Beta c -- Beta IL-3 -- BF-1 -- BF-2 -- BMP1 -- BMP2 -- BMP4 -- BMP7 -- BMP8A mGluR4 -- mGluR5 -- mGluR6 -- Mhox -- MIP-1α -- MIS -- MLH1 -- Mll -- c-Mpl Typ, Huvudkontor. Etableringsår, 2008. Beskriv ditt företag och locka till dig nya affärer (SNI07), Övrig verksamhet inom juridik, ekonomi, vetenskap och teknik Samlade och utgifna af M. P. L. Jacob , Bokivän , Ledamot af alla Afademier .
Omgivningsfuktighet. Max. 95% r.H., icke-kondenserande. Underhåll. Anti Inflammatory Diet: The C?mpl?t? B?ginners Guide t?
Normal Function. Collapse Section. The MPL gene provides instructions for making the thrombopoietin receptor protein, which promotes the growth and division (proliferation) of cells. This receptor is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting.
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Accumulating evidence indicates that the interaction of human LSCs (leukemic stem cells) with the hematopoietic microenvironment, mediated by the thrombopoietin (TPO)/c-MPL pathway, may be an underlying mechanism for resistance to cell cycle-dependent cytotoxic chemotherapy.
Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . the c-mpl gene and of Mpl and Mpl-tr protein. A, the known alternate splice variants of human and mouse c-mpl are depicted in a schematic drawing of the exon/intron structure of c-mpl. TM, trans-membrane.
More detailed investigations of the signal cascades of c-Mpl demonstrated the absence of Jak2 phosphorylation after TPO stimulation in a TAR patient's platelets. A defect in the early events of c-Mpl signal transduction might be the reason for impaired megakaryocytopoiesis in TAR syndrome. PMID: 11012189 [Indexed for MEDLINE] MeSH terms
1999-03-16
Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC and MAPK pathways
In economics, the marginal product of labor is the change in output that results from employing an added unit of labor. It is a feature of the production function, and depends on the amounts of physical capital and labor already in use. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
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Beställningsnr Arbetsområde mbar. Max. tryck bar. MPL-501-A. boost::mpl::int_
MPL ordinarie verksamhetsplanering, följs upp genom fastställd kursplan.
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Anti-TPOR/c-Mpl Antibody is an antibody against TPOR/c-Mpl for use in IP, WB, IH. - Find MSDS or SDS, a COA, data sheets and more information.
MPL is available only to people above 18 years of age. MPL is available in all states where permissible by extant law. Consequently, users located in some states may not be able to access our App or its contests. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.